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Third Eye Chemicals

DISULFIRAM

DISULFIRAM


 

IUPAC NAMEITEM SPECIFICATION
CAS No
97-77-8
Chemical formula C10H20N2S4
APPLICATION For the treatment and management of

chronic alcoholism

EINECS No 200-665-9
Synonyms
Ttd;Tts;DSF;Hoca;TATD;TETD;
DRAM;TTS x;NOXAL;Nocbin

Disulfiram

 

Disulfiram is a drug discovered in the 1920s used to support the treatment of chronic alcoholism by producing an acute sensitivity to ethanol (drinking alcohol). Disulfiram works by inhibiting the enzyme acetaldehyde dehydrogenase, which means that many of the effects of a “hangover” are felt immediately after alcohol is consumed. “Disulfiram plus alcohol, even small amounts, produce flushing, throbbing in head and neck, throbbing headache, respiratory difficulty, nausea, copious vomiting, sweating, thirst, chest pain, palpitation, dyspnea, hyperventilation, tachycardia, hypotension, syncope, marked uneasiness, weakness, vertigo, blurred vision, and confusion. In severe reactions there may be respiratory depression, cardiovascular collapse, arrhythmias, myocardial infarction, acute congestive heart failure, unconsciousness and convulsions

Disulfiram is also being studied as a treatment for cocaine dependence, as it prevents the breakdown of dopamine (a neurotransmitter whose release is stimulated by cocaine); the excess dopamine results in increased anxiety, elevated blood pressure, restlessness, and other unpleasant symptoms. Several studies have reported that it has antiprotozoal activity, as well. Disulfiram is the subject of research for treatment of cancer and HIV (to activate the reservoir of HIV-infected resting CD4 cells).